Labenz J, Gyenes E, Rühl G H, Börsch G
Medizinische Klinik, Elisabeth-Krankenhaus, Essen, Bundesrepublik Deutschland.
Z Gastroenterol. 1992 Nov;30(11):776-8.
In an open study, 62 patients with Helicobacter pylori-associated ulcer disease or functional dyspepsia were treated for two weeks with 2 x 20 mg omeprazole preprandially and 4 x 500 mg amoxicillin suspension one hour before meals and at night. 57 patients (active ulcer disease: n = 53, functional dyspepsia: n = 4) completed the study without contravening the protocol. The rate of eradication of the bacteria at least 4 weeks after cessation of study medication was 82.5% (47/57 patients). Three patients experienced side effects during the treatment period (stomatitis, self-limiting diarrhea, allergic exanthema). In one case allergic exanthema led to discontinuation of therapy. 11 patients with H. pylori-associated ulcer disease received 2 x 20 mg omeprazole for two weeks. In this group no eradication of bacteria was observed.
在一项开放性研究中，62例幽门螺杆菌相关性溃疡病或功能性消化不良患者接受了为期两周的治疗，每天早餐前服用2次20毫克奥美拉唑，阿莫西林混悬液500毫克，于饭前1小时及晚上各服用1次。57例患者（活动性溃疡病：n = 53，功能性消化不良：n = 4）完成了研究且未违反方案。停止研究用药至少4周后的细菌根除率为82.5%（47/57例患者）。3例患者在治疗期间出现副作用（口腔炎、自限性腹泻、过敏性皮疹）。其中1例因过敏性皮疹导致治疗中断。11例幽门螺杆菌相关性溃疡病患者接受了2次20毫克奥美拉唑治疗两周。该组未观察到细菌根除情况。
