Adamek R J, Wegener M, Birkholz S, Opferkuch W, Rühl G H, Ricken D
Medizinische Klinik, St.-Josef-Hospital, Bochum.
Leber Magen Darm. 1992 Nov;22(6):222-4.
Patients with H.pylori positive peptic ulcer disease were treated with a two weeks regimen consisting of 20 mg omeprazole twice daily and 500 mg amoxicillin six times daily. Subsequently, an H2-receptor antagonist was started (300 mg ranitidine) at night time for four weeks. Before and one month after completion of antibiotic therapy an upper GI-tract endoscopy was performed for determination of H.pylori infection [biopsy urease test (BUT), specific culture and histologic demonstration]. A total of 12 patients completed the study protocol. H.pylori eradication, defined as a negative result in BUT, culture and histology) four weeks after completion of the combined omeprazole/amoxicillin treatment regimen was achieved in 91.6% (11 of 12 patients). Complete ulcer healing was confirmed in all patients. A stomatitis was observed in one female patient as a possible side effect of antibiotic treatment, but this did not necessitate discontinuation of therapy. Only complicated drug regimen with many side effects have been available so far for successful eradication of H.pylori. Thus, the present drug combination might prove as an effective therapeutic option in the future. These data, however, await confirmation in larger study population.
幽门螺杆菌阳性消化性溃疡病患者接受了为期两周的治疗方案，该方案包括每日两次服用20毫克奥美拉唑和每日六次服用500毫克阿莫西林。随后，每晚开始服用H2受体拮抗剂（300毫克雷尼替丁），持续四周。在抗生素治疗开始前及治疗结束后一个月进行上消化道内镜检查，以确定幽门螺杆菌感染情况[活检尿素酶试验（BUT）、特异性培养和组织学证明]。共有12名患者完成了研究方案。在完成奥美拉唑/阿莫西林联合治疗方案四周后，以BUT、培养和组织学检查结果为阴性定义的幽门螺杆菌根除率为91.6%（12名患者中的11名）。所有患者均确认溃疡完全愈合。一名女性患者出现了口腔炎，可能是抗生素治疗的副作用，但这并不需要停止治疗。迄今为止，只有复杂且有许多副作用的药物方案可用于成功根除幽门螺杆菌。因此，目前的药物组合未来可能被证明是一种有效的治疗选择。然而，这些数据有待在更大的研究人群中得到证实。
