Moum Bjørn
Medisinsk avdeling, Sykehuset Østfold Fredrikstad, 1601 Fredrikstad.
Tidsskr Nor Laegeforen. 2003 Sep 25;123(18):2565-7.
Ulcerative colitis and Cohn's disease are characterised by exacerbations and remissions. Their aetiology is not known and treatment modalities are therefore focused on the inflammation.
A review is given of the literature on the clinical efficacy and safety of treatment with 5-aminosalicylates.
Aminosalicylic acid has a well-documented efficacy in the acute treatment of mild and moderate ulcerative colitis as well as in maintaining remission in these patients. Its value for patients with Cohn's disease is at the best modest. There are several possible explanations: the variability of disease location, drug disposition and topical availability of the active drug. The usefulness of aminosalicylates has been demonstrated in the long-term treatment of ulcerative colitis for the prevention of colorectal cancer. 5-aminosalicylates have side effects that are comparable with placebo.
The benefit of 5-aminosalicylic acid is well documented in the treatment of active ulcerative colitis and for maintaining remission. The opposite is seen in relation to Cohn's disease.
溃疡性结肠炎和克罗恩病的特点是病情有发作和缓解。其病因不明，因此治疗方式主要针对炎症。
对有关5-氨基水杨酸治疗的临床疗效和安全性的文献进行综述。
氨基水杨酸在轻度和中度溃疡性结肠炎的急性治疗以及维持这些患者的缓解方面有充分记录的疗效。其对克罗恩病患者的价值充其量只是适度的。有几种可能的解释：疾病部位的变异性、药物处置以及活性药物的局部可用性。氨基水杨酸在溃疡性结肠炎的长期治疗中预防结直肠癌的作用已得到证实。5-氨基水杨酸的副作用与安慰剂相当。
5-氨基水杨酸在治疗活动性溃疡性结肠炎和维持缓解方面的益处有充分记录。而在克罗恩病方面则相反。
