Pavlovich S V, Volkov N I, Burlev V A
Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow.
Bull Exp Biol Med. 2003 Oct;136(4):396-8. doi: 10.1023/b:bebm.0000010962.35909.a1.
We compared proliferative activity and levels of steroid receptors in the myometrium and myoma nodes in patients with uterine myoma in different phases of menstrual cycle. Maximum proliferative activity was observed at the periphery of myoma nodes in the the secretory phase of the cycle. The content of progesterone receptors at the periphery and in the center of myoma nodes was lower in the proliferative phase of the cycle than in the secretory phase. Steroid regulation of proliferative activity in the myoma nodes in the the secretory phase through modulation of the content of progesterone receptors is hypothesized.
我们比较了子宫肌瘤患者在月经周期不同阶段子宫肌层和肌瘤结节中的增殖活性及类固醇受体水平。在月经周期的分泌期，肌瘤结节周边观察到最大增殖活性。在月经周期的增殖期，肌瘤结节周边和中心的孕激素受体含量低于分泌期。推测在分泌期，肌瘤结节的增殖活性通过调节孕激素受体含量受到类固醇的调控。
