Anderson R M
Parasite Epidemiology Research Group, Imperial College, London University, UK.
Vaccine. 1992;10(13):928-35. doi: 10.1016/0264-410x(92)90327-g.
The paper focuses on the concepts of transmission success and herd immunity and their relevance to the design of community-based immunization programmes for the control of infectious diseases. Recent work in a number of areas is reviewed, including the influence of mass vaccination on the average age of infection and the incidence of morbidity due to infection and vaccination, the age window of susceptibility and the problems of vaccine programme design in developing countries, the interaction between vaccine efficacy and vaccine safety and the design of vaccination programmes for the control of sexually transmitted infections. Discussions centre on the interplay between an understanding of the transmission dynamics of an infection and the design of community-based control programmes.
本文聚焦于传播成功和群体免疫的概念，以及它们与基于社区的传染病防控免疫规划设计的相关性。回顾了多个领域的近期研究工作，包括大规模疫苗接种对平均感染年龄以及感染和疫苗接种所致发病率的影响、易感年龄窗口以及发展中国家疫苗规划设计问题、疫苗效力与疫苗安全性之间的相互作用，以及用于控制性传播感染的疫苗接种规划设计。讨论集中在对感染传播动态的理解与基于社区的防控规划设计之间的相互作用。
