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一项关于腰椎间盘突出症和腰椎管狭窄症患者神经根周围浸润治疗神经根性疼痛的前瞻性队列研究结果

Outcomes of a prospective cohort study on peri-radicular infiltration for radicular pain in patients with lumbar disc herniation and spinal stenosis.

作者信息

Ng Leslie Chong Lich, Sell Philip

机构信息

Orthopaedic Surgery Department, Leicester General Hospital, Gwendolen road, LE5 4PW, Leicester, UK.

出版信息

Eur Spine J. 2004 Jul;13(4):325-9. doi: 10.1007/s00586-003-0649-1. Epub 2004 Jan 9.

Abstract

The purpose of this study was to assess the outcome of peri-radicular infiltration for radicular pain in patients with spinal stenosis and lumbar disc herniation (LDH). Patients with spinal stenosis ( n=62) or LDH ( n=55) who met our criteria received fluoroscopically guided peri-radicular infiltration of local anaesthetic and steroid at the site of documented pathology. All the patients were followed-up at 3 months. There was a statistically significant difference in the functional outcome between the spinal stenosis group and the LDH group. The mean change in the Oswestry disability index (ODI) score for the spinal stenosis group was 5.5% compared to 12% for the LDH group. The spinal stenosis group had a mean change in visual analogue scales (VAS) of 1.2 compared to 2 for the LDH group. The higher the modified somatic perception score, modified zung depression and age at injection, the less favourable the outcome. There was a significantly better response to peri-radicular infiltration for radicular pain in patients with LDH than the spinal stenosis. Our findings help us to provide a better information for future patients. We do not know if this is a treatment effect or natural history of the pathology, as this is a cohort study and not a randomised controlled trial.

摘要

本研究的目的是评估在患有椎管狭窄症和腰椎间盘突出症(LDH)的患者中,神经根周围浸润治疗神经根性疼痛的效果。符合我们标准的椎管狭窄症患者(n = 62)或LDH患者(n = 55)在记录的病变部位接受了在荧光镜引导下的局部麻醉剂和类固醇的神经根周围浸润。所有患者均在3个月时进行随访。椎管狭窄症组和LDH组之间的功能结果存在统计学上的显著差异。椎管狭窄症组的Oswestry功能障碍指数(ODI)评分平均变化为5.5%,而LDH组为12%。椎管狭窄症组的视觉模拟量表(VAS)平均变化为1.2,而LDH组为2。改良躯体感觉评分、改良zung抑郁评分和注射时年龄越高,结果越不理想。与椎管狭窄症患者相比,LDH患者对神经根周围浸润治疗神经根性疼痛的反应明显更好。我们的研究结果有助于为未来的患者提供更好的信息。由于这是一项队列研究而非随机对照试验,我们不知道这是治疗效果还是病变的自然病程。

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