[楚瓦什亚的群体遗传结构（基于核基因组中八个DNA位点的数据）]

[Population-genetic structure of Chuvashia (from data on eight DNA loci in the nuclear genome)].

作者信息

Khusnutdinova E K, Viktorova T V, Akhmetova V L, Mustafina O E, Fatkhlislamova R I, Balanovskaia E V, Petrova N V, Makarov S V, Kravchuk O I, Paĭ G V, Ginter E K

机构信息

Institute of Biochemistry and Genetics, Russian Academy of Sciences, Ufa, 450054 Bashkortostan, Russia.

出版信息

Genetika. 2003 Nov;39(11):1550-63.

PMID:14714469

Abstract

Population-genetic study of indigenous populations representing three ethnic Chuvash group: highland (Cheboksarsk and Morgaush district), lowland (Kanash district) and mid-lowland (Marposad district). Eight polymorphic DNA loci of the nuclear genome (VNTR/PAH, STR/PAH, VNTR/ApoB, VNTR/DAT1, APF, VNTR/eNOS, IVS6aGATT, and KM.19/PstI) were examined in the population of each district. For each of the four population, we estimated the allele and genotype frequency distributions at each polymorphic system, heterozygosities HS and between-population differences FST. In the combined Chuvash sample, HS = 0.464 and FST = 0.006. Loci VNTR(DAT) and VNTR(ApoB) showed highest between-population differentiation (0.009 < or = FST < or = 0.012), and loci IVS6aGATT, APF, VNTR/eNOS, and D7S23 (KM.19), lowest differentiation (0.001 < or = FST < or = 0.003). Analysis of genetic distances revealed somewhat higher genetic similarity between the Cheboksarsk and Morgaush populations belonging to the highland Chuvash group, whereas the highland Chuvash population from the Marposad district, which belong to the mid-lowland group, was more distant from the former populations.

摘要

对代表楚瓦什三个族群的原住民群体进行的群体遗传学研究

高地群体（切博克萨雷和莫尔高什区）、低地群体（卡纳什区）和中低地群体（马尔波萨德区）。在每个区的群体中检测了核基因组的8个多态性DNA位点（VNTR/PAH、STR/PAH、VNTR/ApoB、VNTR/DAT1、APF、VNTR/eNOS、IVS6aGATT和KM.19/PstI）。对于这四个群体中的每一个，我们估计了每个多态系统的等位基因和基因型频率分布、杂合度HS以及群体间差异FST。在合并的楚瓦什样本中，HS = 0.464，FST = 0.006。VNTR（DAT）和VNTR（ApoB）位点显示出最高的群体间分化（0.009≤FST≤0.012），而IVS6aGATT、APF、VNTR/eNOS和D7S23（KM.19）位点的分化最低（0.001≤FST≤0.003）。遗传距离分析显示，属于高地楚瓦什群体的切博克萨雷和莫尔高什群体之间的遗传相似性略高，而属于中低地群体的马尔波萨德区的高地楚瓦什群体与前两个群体的距离更远。