Division of Microbiology & Molecular Genetics, School of Medicine, Loma Linda, CA 92350, USA.
Future Microbiol. 2012 Apr;7(4):497-512. doi: 10.2217/fmb.12.17.
Porphyromonas gingivalis, a black-pigmented, Gram-negative anaerobe, is an important etiologic agent of periodontal disease. The harsh inflammatory condition of the periodontal pocket implies that this organism has properties that will facilitate its ability to respond and adapt to oxidative stress. Because the stress response in the pathogen is a major determinant of its virulence, a comprehensive understanding of its oxidative stress resistance strategy is vital. We discuss multiple mechanisms and systems that clearly work in synergy to defend and protect P. gingivalis against oxidative damage caused by reactive oxygen species. The involvement of multiple hypothetical proteins and/or proteins of unknown function in this process may imply other unique mechanisms and potential therapeutic targets.
牙龈卟啉单胞菌是一种黑色着色、革兰氏阴性厌氧菌，是牙周病的重要病因。牙周袋内恶劣的炎症环境意味着该生物具有促进其应对和适应氧化应激的特性。由于病原体的应激反应是其毒力的主要决定因素，因此全面了解其抗氧化应激抵抗策略至关重要。我们讨论了多种机制和系统，这些机制和系统显然协同作用，保护牙龈卟啉单胞菌免受活性氧引起的氧化损伤。在这个过程中，多个假定蛋白和/或功能未知的蛋白的参与可能意味着其他独特的机制和潜在的治疗靶点。
