分析影响冻融胚胎成功率的因素。
Analyzing factors affecting the success rate of frozen-thawed embryos.
作者信息
Lahav-Baratz S, Koifman M, Shiloh H, Ishai D, Wiener-Megnazi Z, Dirnfeld M
机构信息
Department of Obstetric and Gynecology, IVF unit, Carmel Medical Center, Haifa, Israel.
出版信息
J Assist Reprod Genet. 2003 Nov;20(11):444-8. doi: 10.1023/b:jarg.0000006705.46147.a2.
PURPOSE
In recent years the infertile population applying for IVF treatments was changed and so the indications for performing intracellular sperm injection (ICSI). The aim of this study was to analyze predicting factors of our thawing cycles.
METHODS
From December 1998 to July 2001, 440 consecutive thawing cycles were performed. Patient characteristics were examined. The number of cryopreserved embryos, number of transferred embryos, the timing of cryopreservation (48 h vs. 72 h), and embryo survival rate were analyzed as a possible predictor for pregnancies achievement.
RESULTS
Conventional IVF patient's characteristic was significantly different from ICSI population and analysis has been performed for every population separately. In the IVF population the women age, the number of transferred embryos, and timing of cryopreservation were factors significantly influencing the pregnancy rate. Interestingly, in the ICSI population only the number of transferred embryos was found to be a predictive factor.
CONCLUSION
ICSI and IVF cycles should be analyzed separately. Not all the factors influencing the success rate in the conventional IVF population are valid in the ICSI population.
目的
近年来，申请体外受精（IVF）治疗的不孕人群发生了变化，因此卵胞浆内单精子注射（ICSI）的适应证也有所改变。本研究的目的是分析我们解冻周期的预测因素。
方法
1998年12月至2001年7月，连续进行了440个解冻周期。对患者特征进行了检查。分析冷冻胚胎数量、移植胚胎数量、冷冻时间（48小时与72小时）以及胚胎存活率作为妊娠成功的可能预测因素。
结果
常规IVF患者的特征与ICSI人群有显著差异，且对每个群体分别进行了分析。在IVF群体中，女性年龄、移植胚胎数量和冷冻时间是显著影响妊娠率的因素。有趣的是，在ICSI人群中，仅发现移植胚胎数量是一个预测因素。
结论
ICSI和IVF周期应分别进行分析。并非所有影响常规IVF群体成功率的因素在ICSI群体中都有效。
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