Goldenberg Robert L, Culhane Jennifer Flatow
Division of Maternal-Fetal Medicine, Department of Obstetrics/Gynecology, University of Alabama at Birmingham, 1500 6th Avenue S., CRWH 379, Birmingham, AL 35233, USA.
Clin Perinatol. 2003 Dec;30(4):677-700. doi: 10.1016/s0095-5108(03)00110-6.
In summary, there is little question that intrauterine and some extrauterine infections play important roles in the etiology of early, spontaneous, preterm labor and PROM. Disappointing are the mixed results from various treatment attempts, usually with antibiotics, to reduce the preterm birth rate. Clearly, a better understanding of the pathways leading from infection to preterm birth will be necessary to develop effective interventions to reduce infection-related preterm delivery. Research must also address the question of individual susceptibility to infections and the influence of other exposures that may moderate the association between infection and preterm birth.
总之，毫无疑问，宫内感染和一些宫外感染在早期、自发性早产和胎膜早破的病因中起着重要作用。令人失望的是，各种通常使用抗生素的治疗尝试在降低早产率方面取得的结果参差不齐。显然，要制定有效的干预措施以减少与感染相关的早产，就必须更好地了解从感染到早产的途径。研究还必须解决个体对感染的易感性问题，以及其他可能调节感染与早产之间关联的暴露因素的影响。
