Yamazaki Kazuo, Kondo Yoshinori
Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai 980-8578, Japan.
J Comb Chem. 2004 Jan-Feb;6(1):121-5. doi: 10.1021/cc034029l.
Palladium-catalyzed carbonylation, which was based on a ligand exchange reaction, efficiently converted immobilized aryl halides to amides under mild reaction conditions using molybdenum hexacarbonyl [Mo(CO)(6)] as the carbon monoxide source. The method easily operates without irradiating with microwaves and yields a wide range of highly pure amides after cleaving from the resin. The method could also be applied to the carbonylation of immobilized amines with aryl halides and to construct heterocyclic systems via a carbonylative cyclization.
基于配体交换反应的钯催化羰基化反应，在温和的反应条件下，使用六羰基钼[Mo(CO)₆]作为一氧化碳源，能有效地将固定化芳基卤化物转化为酰胺。该方法无需微波辐射即可轻松操作，从树脂上裂解后可得到多种高纯度的酰胺。该方法还可应用于固定化胺与芳基卤化物的羰基化反应，以及通过羰基化环化构建杂环体系。
