5-溴降冰片-2-烯-7-酮衍生物作为钯催化羰基化反应的一氧化碳源
5-Bromo-norborn-2-en-7-one derivatives as a carbon monoxide source for palladium catalyzed carbonylation reactions.
作者信息
Payne China M, Cho Kyulee, Larsen David S
机构信息
Department of Chemistry, University of Otago P.O. Box 56 Dunedin 9054 New Zealand
出版信息
RSC Adv. 2019 Sep 30;9(53):30736-30740. doi: 10.1039/c9ra06594f. eCollection 2019 Sep 26.
Norbornenone (5b), obtained from the reaction of 2,5-dimethyl-3,4-diphenylcyclopentadienone dimer (3) with bromomaleic anhydride (4b), provides an excellent base-triggered source of carbon monoxide for palladium-catalysed carbonylation reactions. Aminocarbonylation, ketoamide synthesis, and Suzuki-Miyaura reactions of aryl iodides carried out in a two-chamber reaction vessel gave good to excellent yields of carbonylated products.
降冰片烯酮（5b）由2,5-二甲基-3,4-二苯基环戊二烯酮二聚体（3）与溴马来酸酐（4b）反应制得，为钯催化的羰基化反应提供了一种优良的碱引发一氧化碳源。在两腔反应容器中进行的芳基碘化物的氨基羰基化、酮酰胺合成及铃木-宫浦反应，得到了产率良好至优异的羰基化产物。
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