Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
J Org Chem. 2010 Dec 17;75(24):8410-5. doi: 10.1021/jo101611g. Epub 2010 Nov 18.
A simple method for the synthesis of amides has been developed by molybdenum-mediated carbamoylation of aryl halides. Whereas the conventional palladium-catalyzed three-component coupling reaction requires a large excess of gaseous carbon monoxide, the incorporation of carbon monoxide in this Mo-mediated carbamoylation reaction is so efficient that it requires only a slight excess amount of carbon monoxide in the form of its molybdenum complex, Mo(CO)(6). The reaction is applicable for the synthesis of a wide variety of not only secondary and tertiary amides but also primary amides by using aqueous ammonia.
一种通过钼介导的卤代芳烃氨甲酰化反应合成酰胺的简单方法已经被开发出来。虽然传统的钯催化的三组分偶联反应需要大量过量的气态一氧化碳，但在这种钼介导的氨甲酰化反应中，一氧化碳的掺入效率非常高，只需要以钼配合物 Mo(CO)(6)的形式稍微过量的一氧化碳。该反应不仅适用于合成各种仲酰胺和叔酰胺，而且适用于通过水合氨合成各种伯酰胺。
