Gellermann Werner, Bernstein Paul S
Department of Physics and Dixon Laser Institute, University of Utah, Salt Lake City, Utah, USA.
J Biomed Opt. 2004 Jan-Feb;9(1):75-85. doi: 10.1117/1.1628240.
There is currently strong interest in developing noninvasive technologies for the detection of macular carotenoid pigments in the human eye. These pigments, consisting of lutein and zeaxanthin, are taken up from the diet and are thought to play an important role in the prevention of age-related macular degeneration, the leading cause of blindness in the elderly in the Western world. It may be possible to prevent or delay the onset of this debilitating disease with suitable dietary intervention strategies. We review the most commonly used detection techniques based on heterochromatic flicker photometry, fundus reflectometry, and autofluorescense techniques and put them in perspective with recently developed more molecule-specific Raman detection methods.
目前，人们对开发用于检测人眼黄斑区类胡萝卜素色素的非侵入性技术有着浓厚的兴趣。这些色素由叶黄素和玉米黄质组成，从饮食中摄取，被认为在预防年龄相关性黄斑变性中起着重要作用，年龄相关性黄斑变性是西方世界老年人失明的主要原因。通过适当的饮食干预策略，有可能预防或延缓这种使人衰弱的疾病的发作。我们回顾了基于异色闪烁光度法、眼底反射ometry和自发荧光技术的最常用检测技术，并将它们与最近开发的更具分子特异性的拉曼检测方法进行了比较。
