Rinaldi Michele, Galantuomo Nicola, Passaro Maria Laura, Cennamo Gilda, Chiosi Flavia, Costagliola Ciro
Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples "Federico II", 80131 Napoli, Italy.
Department of Medicine and Health Sciences "V. Tiberio", University of Molise, 86100 Campobasso, Italy.
J Clin Med. 2025 Jan 6;14(1):290. doi: 10.3390/jcm14010290.
: This study aimed to assess the role of macular pigment optical density (MPOD) in patients with a full-thickness macular hole (FTMH) compared to healthy controls, evaluating postoperative changes in MPOD and exploring potential correlations with visual outcomes. : This prospective, cross-sectional, comparative study included 16 eyes from FTMH patients who achieved anatomical hole closure following pars plana vitrectomy with the inverted ILM flap technique. Each eye underwent a comprehensive ophthalmologic examination, including BCVA and intraocular pressure measurements, anterior segment evaluation, fundus examination, and macular assessment with Enhanced Depth Imaging Optical Coherence Tomography (EDI-OCT, Spectralis, Heidelberg Engineering Inc., Heidelberg, Germany). Macular pigment optical density (MPOD) was measured using one-wavelength reflectometry (Visucam 200, Zeiss Meditec, Jena, Germany). These evaluations were conducted preoperatively and at 1, 3, and 6 months postoperatively to assess changes over time and correlate MPOD with visual outcomes. : Significant baseline differences were observed between FTMH patients and controls for BCVA, mean MPOD, maximum MPOD, and MPOD volume ( < 0.05). Postoperative BCVA improved significantly ( = 0.0011), with a notable increase in MPOD volume at 6 months ( = 0.01). A positive correlation was found between BCVA improvement and MPOD volume increase (r = 0.739; = 0.002). : In conclusion, MPOD measurement may serve as a valuable addition to the follow-up of FTMH surgery, providing insights into photoreceptor function and macular metabolic activity, potentially correlating with visual recovery. Further longitudinal studies are needed to clarify its relationship with clinical variables, such as metamorphopsia and OCT microstructural findings.
本研究旨在评估与健康对照相比，黄斑色素光密度（MPOD）在全层黄斑裂孔（FTMH）患者中的作用，评估MPOD的术后变化，并探索其与视觉结果的潜在相关性。本前瞻性、横断面、对照研究纳入了16只接受了玻璃体切割联合内界膜翻转覆盖技术且实现解剖学裂孔闭合的FTMH患者的眼睛。每只眼睛均接受了全面的眼科检查，包括最佳矫正视力（BCVA）和眼压测量、眼前节评估、眼底检查以及使用增强深度成像光学相干断层扫描（EDI-OCT，德国海德堡工程公司的Spectralis）进行黄斑评估。使用单波长反射测量法（德国蔡司医疗技术公司的Visucam 200）测量黄斑色素光密度（MPOD）。这些评估在术前以及术后1个月、3个月和6个月进行，以评估随时间的变化，并将MPOD与视觉结果相关联。FTMH患者与对照组在BCVA、平均MPOD、最大MPOD和MPOD体积方面观察到显著的基线差异（P<0.05）。术后BCVA显著改善（P = 0.0011），6个月时MPOD体积显著增加（P = 0.01）。发现BCVA改善与MPOD体积增加之间存在正相关（r = 0.739；P = 0.002）。总之，MPOD测量可能是FTMH手术随访的一项有价值的补充，有助于了解光感受器功能和黄斑代谢活动，可能与视觉恢复相关。需要进一步的纵向研究来阐明其与诸如视物变形和OCT微观结构发现等临床变量的关系。
