Boini Stéphanie, Briançon Serge, Guillemin Francis, Galan Pilar, Hercberg Serge
EA 3444 - Ecole de Santé Publique, Faculté de médecine, Université Henry Poincaré de Nancy, 9 avenue de la forêt de Haye, BP 184, 54500 Vandoeuvre Les Nancy, France.
Health Qual Life Outcomes. 2004 Jan 9;2:4. doi: 10.1186/1477-7525-2-4.
Investigations focusing and implementing on the impact of cancer on health-related quality of life (HRQoL) by the way of a mean comparison between cancer patients and subjects from the general population, are scarce and usually cross-sectional. Longitudinal application of HRQoL instruments to a general, initially healthy population allows for change to be assessed as an event occurs, rather than afterwards. The objective of the present study was to investigate the impact of new cancer on HRQoL.
The 36-item Short Form (SF-36) and 12-item General Health Questionnaire (GHQ-12) were applied to the French SU.VI.MAX cohort in 1996 and 1998. A controlled longitudinal study was used to determine the impact on HRQoL of newly diagnosed cancer: 84 patients with cancer that occurred between the 2 HRQoL measures were compared with 420 age- and sex-matched cancer-free controls.
Initial HRQoL level was similar in the two groups. A new cancer had a particularly marked effect on the SF-36 Physical functioning, Role-physical and General health dimensions (more than 6.6-point difference in change in HRQoL evolution on a 0-100 scale). The Bodily pain and Vitality dimensions were less severely affected (difference in change varying from 4.4 to 6.3 points), and there was no effect on either the GHQ-12 score or the SF-36 Mental health, Role-emotional and Social functioning dimensions.
The negative impact of cancer on the lives of patients was assessed in terms of HRQoL. The aspects most likely to be affected were those with a physical component, and general health perceptions. These results can thus help quantify the impact of a new cancer on HRQoL evolution and potentially facilitate early intervention by identifying the most affected HRQoL domains.
通过比较癌症患者与普通人群的均值来关注和实施癌症对健康相关生活质量（HRQoL）影响的研究较少，且通常为横断面研究。将HRQoL工具纵向应用于一般的、最初健康的人群，可以在事件发生时而非之后评估变化。本研究的目的是调查新发癌症对HRQoL的影响。
1996年和1998年，对法国SU.VI.MAX队列应用了36项简短健康调查问卷（SF-36）和12项一般健康问卷（GHQ-12）。采用对照纵向研究来确定新诊断癌症对HRQoL的影响：将在两次HRQoL测量之间发生癌症的84例患者与420例年龄和性别匹配的无癌对照进行比较。
两组的初始HRQoL水平相似。新发癌症对SF-36身体功能、角色-身体和总体健康维度有特别显著的影响（在0-100分的HRQoL演变变化中差异超过6.6分）。身体疼痛和活力维度受影响较小（变化差异在4.4至6.3分之间），对GHQ-12评分或SF-36心理健康、角色-情感和社会功能维度均无影响。
从HRQoL的角度评估了癌症对患者生活的负面影响。最可能受影响的方面是那些具有身体成分和总体健康感知的方面。因此，这些结果有助于量化新发癌症对HRQoL演变的影响，并可能通过识别受影响最大的HRQoL领域来促进早期干预。
