Wurnig C, Eyb R, Auersperg V
Vienna University Department of Orthopedics, Allgemeines Krankenhaus, Austria.
Acta Orthop Scand. 1992 Dec;63(6):628-30. doi: 10.1080/17453679209169723.
In a prospective series of 100 patients we investigated the effect of indomethacin for 6 weeks in the prophylaxis of ectopic bone formation in hip replacements with cementless fixation. Indomethacin prophylaxis reduced (P < 0.0001) ectopic bone formation compared to a retrospective control group of equal size. Side-effects occurred in one-fifth of the patients, but most of these could continue the medication for at least 4 weeks.
在一项针对100例患者的前瞻性研究中，我们调查了吲哚美辛在非骨水泥固定髋关节置换术中预防异位骨形成的6周疗效。与同等规模的回顾性对照组相比，吲哚美辛预防措施减少了异位骨形成（P < 0.0001）。五分之一的患者出现了副作用，但其中大多数患者能够继续用药至少4周。
