Radi Z A, Miller D L, Hines M E
Veterinary Diagnostic and Investigational Laboratory, The University of Georgia, 43 Brighton Road, PO Box 1389, Tifton, GA 31793, USA).
Vet Pathol. 2004 Jan;41(1):75-8. doi: 10.1354/vp.41-1-75.
A bilateral testicular neoplasm from an 11-year-old mixed-breed male dog was removed surgically and examined histologically. The neoplasm was nonencapsulated and composed of acinar and tubular structures lined by one or more layers of neoplastic polyhedral epithelial cells with an abundant mucinous secretion. On histochemistry, all neoplastic cells and associated secretions were periodic acid-Schiff positive. Some neoplastic cells and all associated secretions were positive on mucicarmine stain, and some neoplastic cells, all the stroma, and associated secretions were positive on alcian blue stain. On immunohistochemistry, the neoplastic cells had strong diffuse cytoplasmic immunoreactivity for cytokeratin and vimentin, weak scattered cytoplasmic immunoreactivity for carcinoembryonic antigen and neuron-specific enolase, and no immunoreactivity for S-100. On the basis of histopathology, histochemistry, and immunohistochemical findings, a diagnosis of mucinous adenocarcinoma of rete testis was made. Rete testis adenocarcinoma is a well known but very rare neoplasm in humans. To our knowledge, this is the first report of the mucinous variant of adenocarcinoma of the rete testis in a dog.
对一只11岁的杂种雄性犬的双侧睾丸肿瘤进行了手术切除并进行组织学检查。该肿瘤无包膜，由腺泡和管状结构组成，内衬一层或多层具有丰富黏液分泌的肿瘤性多面体上皮细胞。组织化学检查显示，所有肿瘤细胞及相关分泌物对过碘酸-希夫反应呈阳性。部分肿瘤细胞及所有相关分泌物对黏液卡红染色呈阳性，部分肿瘤细胞、所有间质及相关分泌物对阿尔辛蓝染色呈阳性。免疫组织化学检查显示，肿瘤细胞对细胞角蛋白和波形蛋白具有强弥漫性细胞质免疫反应性，对癌胚抗原和神经元特异性烯醇化酶具有弱散在细胞质免疫反应性，对S-100无免疫反应性。根据组织病理学、组织化学和免疫组织化学检查结果，诊断为睾丸网黏液腺癌。睾丸网腺癌在人类中是一种已知但非常罕见的肿瘤。据我们所知，这是犬睾丸网腺癌黏液变异型的首例报道。
