Crookes Wendy J, Ding Lin-Lin, Huang Qing Ling, Kimbell Jennifer R, Horwitz Joseph, McFall-Ngai Margaret J
Kewalo Marine Laboratory, Pacific Biomedical Research Center, University of Hawaii-Manoa, 41 Ahui Street, Honolulu, HI 96813, USA.
Science. 2004 Jan 9;303(5655):235-8. doi: 10.1126/science.1091288.
A family of unusual proteins is deposited in flat, structural platelets in reflective tissues of the squid Euprymna scolopes. These proteins, which we have named reflectins, are encoded by at least six genes in three subfamilies and have no reported homologs outside of squids. Reflectins possess five repeating domains, which are highly conserved among members of the family. The proteins have a very unusual composition, with four relatively rare residues (tyrosine, methionine, arginine, and tryptophan) comprising approximately 57% of a reflectin, and several common residues (alanine, isoleucine, leucine, and lysine) occurring in none of the family members. These protein-based reflectors in squids provide a marked example of nanofabrication in animal systems.
一类不同寻常的蛋白质沉积在乌贼（Euprymna scolopes）反射组织中的扁平结构血小板中。我们将这些蛋白质命名为反射蛋白，它们由三个亚家族中的至少六个基因编码，并且在乌贼之外没有报道过同源物。反射蛋白具有五个重复结构域，在该家族成员中高度保守。这些蛋白质的组成非常独特，四种相对罕见的氨基酸（酪氨酸、甲硫氨酸、精氨酸和色氨酸）约占反射蛋白的57%，而几种常见氨基酸（丙氨酸、异亮氨酸、亮氨酸和赖氨酸）在该家族成员中均未出现。乌贼中这些基于蛋白质的反射器是动物系统中纳米制造的一个显著例子。
