Mihas Anastasios A, Lawson Patricia B, Dreiling Bernard J, Gurram V S, Heuman Douglas M
Division of Gastroenterology, Virginia Commonwealth University Health System and the McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USA.
Int J Gastrointest Cancer. 2003;33(2-3):123-7. doi: 10.1385/IJGC:33:2-3:123.
There is much confusion in the literature regarding the differences between Mikulicz disease and Mikulicz syndrome. This may be because there seems to be a connection between the disease and disease processes associated with the syndrome. This article provides historical data discussing the emergence of Mikulicz disease, confusions regarding its definition, and finally offers an explanation to the interrelationships of these two entities. This case report hypothesizes that the non-Hodgkin's lymphoma (NHL), which in association with Sjögren's syndrome and Mikulicz disease in this patient comprised the Mikulicz syndrome, may have transformed into his malignant large-cell gastric lymphoma. It supports conclusions in the literature that Mikulicz disease, benign lymphoepithelial lesion, and Sjögren's syndrome may all be a part of the same disease process as graduated variants of one another, with malignant lymphoma being a recognized complication of these entities.
关于米库利奇病（Mikulicz disease）和米库利奇综合征（Mikulicz syndrome）之间的差异，文献中存在诸多混淆。这可能是因为该疾病与综合征相关的疾病过程之间似乎存在联系。本文提供了历史数据，讨论了米库利奇病的出现、关于其定义的混淆之处，并最终对这两个实体的相互关系给出了解释。本病例报告推测，在该患者中与干燥综合征（Sjögren's syndrome）和米库利奇病相关的非霍奇金淋巴瘤（non-Hodgkin's lymphoma，NHL）可能已转变为其恶性大细胞胃淋巴瘤。它支持了文献中的结论，即米库利奇病、良性淋巴上皮病变和干燥综合征可能都是同一疾病过程的一部分，彼此之间是渐进的变体，恶性淋巴瘤是这些实体公认的并发症。
