急性冠状动脉综合征中锌及脂质过氧化水平

Levels of zinc and lipid peroxidation in acute coronary syndrome.

作者信息

Cikim Gurkan, Canatan Halit, Gursu M Ferit, Gulcu Funda, Baydas Giyaseddin, Kilicoglu A Erhan

机构信息

Department of Biochemistry, College of Medicine, Mustafa Kemal University, Hatay, Turkey.

出版信息

Biol Trace Elem Res. 2003 Winter;96(1-3):61-9. doi: 10.1385/BTER:96:1-3:61.

DOI:10.1385/BTER:96:1-3:61

PMID:14716086

Abstract

The present study was carried out on 20 female patients diagnosed with acute coronary syndrome (ACS). The control group was composed of 20 healthy female volunteers. Plasma malondialdehyde (MDA) levels and serum zinc (Zn), total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and VLDL-cholesterol, Lp(a), Apo-A1, and Apo-B were determined in all patients and controls. Plasma MDA levels were determined to be significantly high in patients with ACS compared to the controls (1.75+/-0.27 vs 0.8+/-0.43 nmol/mL; p<0.05). On the other hand, Zn levels in patients with ACS were determined to be significantly low compared to the control group (67.9+/-14.8 vs 101.8+/-22.4 mg/dL; p<0.05). There was a statistically significant negative correlation between MDA and Zn levels in patients with ACS (r = -0.678, p<0.05). Other lipid parameters were significantly altered in patients with ACS compared to the controls (p<0.05). In conclusion, Zn and lipid peroxidation levels are important in patients with ACS and they must be monitored during diagnosis and treatment of these patients.

摘要

本研究对20例诊断为急性冠状动脉综合征（ACS）的女性患者进行。对照组由20名健康女性志愿者组成。测定了所有患者和对照组的血浆丙二醛（MDA）水平以及血清锌（Zn）、总胆固醇、低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇、极低密度脂蛋白（VLDL）胆固醇、脂蛋白（a）[Lp(a)]、载脂蛋白A1（Apo-A1）和载脂蛋白B（Apo-B）。结果显示，与对照组相比，ACS患者的血浆MDA水平显著升高（1.75±0.27 vs 0.8±0.43 nmol/mL；p<0.05）。另一方面，与对照组相比，ACS患者的锌水平显著降低（67.9±14.8 vs 101.8±22.4 mg/dL；p<0.05）。ACS患者中MDA与锌水平之间存在显著的负相关（r = -0.678，p<0.05）。与对照组相比，ACS患者的其他脂质参数也有显著改变（p<0.05）。总之，锌和脂质过氧化水平在ACS患者中很重要，在这些患者的诊断和治疗过程中必须对其进行监测。