Lafita J
Servicio de Endocrinología, Centro de Consultas Príncipe de Viana, Pamplona, 31008, Spain.
An Sist Sanit Navar. 2003;26 Suppl 3:7-15.
The bone tissue is one of the largest of the organism, with clear functions: to serve as a support and protection for the soft parts, as support for movement with the anchorage of the muscles, as mineral reserve and as interactive storage of the bone marrow. To exercise all these functions the bone must maintain its quality, a concept that combines its degree of mineralisation, its microarchitecture and its capacity to repair lesions, aspects that are included in the broad definition of osteoporosis: "A systemic disease of the skeleton, characterised by a low bone mass and a deterioration of the microarchitecture of the bone tissue, which jointly result in an increase in bone fragility and the consequent increase of the risk of fractures", although from the clinical point of view we have to centre our attention on mineralisation, a quantifiable aspect, understanding as osteoporosis a fall in bone mass greater than 2.5 standard deviations below that of young healthy patients. This article reviews the physiopathological aspects that influence the development of this frequent clinical picture.
骨组织是机体最大的组织之一，具有明确的功能：为软组织提供支撑和保护，通过肌肉附着支持运动，作为矿物质储备以及作为骨髓的交互储存场所。为行使所有这些功能，骨骼必须保持其质量，这一概念涵盖其矿化程度、微观结构及其修复损伤的能力，这些方面都包含在骨质疏松症的广义定义中：“一种全身性骨骼疾病，其特征是骨量低和骨组织微观结构恶化，共同导致骨脆性增加以及随之而来的骨折风险增加”，尽管从临床角度来看，我们必须将注意力集中在矿化这一可量化的方面，将骨量比年轻健康患者低超过2.5个标准差的情况理解为骨质疏松症。本文综述了影响这种常见临床情况发生发展的生理病理方面。
