CD24表达是低级别或器官局限性前列腺癌中前列腺特异性抗原（PSA）复发及预后不良的重要预测指标。
CD24 expression is a significant predictor of PSA relapse and poor prognosis in low grade or organ confined prostate cancer.
作者信息
Kristiansen Glen, Pilarsky Christian, Pervan Janja, Stürzebecher Burkhard, Stephan Carsten, Jung Klaus, Loening Stefan, Rosenthal Andre, Dietel Manfred
机构信息
Institute of Pathology, Charité University Hospital, Berlin, Germany.
出版信息
Prostate. 2004 Feb 1;58(2):183-92. doi: 10.1002/pros.10324.
BACKGROUND
The prognostic impact of tumor grading and staging is markedly reduced in organ confined or moderately differentiated prostate cancer, which underscores the importance of new prognostic markers. Evaluating public expression data of prostate cancer, we found an upregulation of the candidate gene CD24.
METHODS
We examined immunohistochemically the expression of CD24 protein in 31 nodal metastases and 102 adenocarcinomas of the prostate and correlated our findings to clinicopathological parameters.
RESULTS
CD24 expression was found in 48% of primary prostate cancer cases and in 68% of lymph node metastases. Kaplan Meier curves and Cox regression analysis showed that CD24 expression was strongly linked to significantly earlier disease progression (relative risk = 3.2), which was especially pronounced in organ confined, or moderately differentiated primary prostate tumors.
CONCLUSIONS
We conclude that CD24 is an important prognostic tissue marker for prostate cancer which could help to define patients of low or high risk of recurrence.
背景
在器官局限性或中度分化的前列腺癌中，肿瘤分级和分期对预后的影响显著降低，这凸显了新的预后标志物的重要性。通过评估前列腺癌的公共表达数据，我们发现候选基因CD24表达上调。
方法
我们采用免疫组织化学方法检测了31例前列腺淋巴结转移灶和102例前列腺腺癌中CD24蛋白的表达情况，并将我们的研究结果与临床病理参数进行了关联分析。
结果
在48%的原发性前列腺癌病例和68%的淋巴结转移灶中发现了CD24表达。Kaplan Meier曲线和Cox回归分析表明，CD24表达与疾病进展明显提前密切相关（相对风险=3.2），这在器官局限性或中度分化的原发性前列腺肿瘤中尤为明显。
结论
我们得出结论，CD24是前列腺癌的一个重要预后组织标志物，有助于确定复发风险低或高的患者。
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