Cushnie T P Tim, Hamilton Vivienne E S, Lamb Andrew J
School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen, AB10 1FR, UK.
Microbiol Res. 2003;158(4):281-9. doi: 10.1078/0944-5013-00206.
Activity of the flavonoids apigenin, baicalin and galangin against sensitive and antibiotic resistant strains of Staphylococculs aureus, Enterococcus faecalis, E. faecium, Escherichia coli and Pseudomonas aeruginosa was investigated. Using an agar dilution assay, galangin was shown to have a minimum inhibitory concentration (MIC) of 25 to 50 microg/mL against all six strains of S. aureus but negligible activity against the othe species. Apigenin displayed only marginal activity against S. aureus and no activity was detected from baicalin. In inhibition curve studies, galangin caused a 100,000-fold decrease in the viability of a growing population of S. aureus NCTC 6571 within the first two hours of treatment. Decreases in viability of S. aureus NCTC 11561 and NCIMB 9968 populations were also observed.
研究了黄酮类化合物芹菜素、黄芩苷和高良姜素对金黄色葡萄球菌、粪肠球菌、屎肠球菌、大肠杆菌和铜绿假单胞菌的敏感菌株及抗生素耐药菌株的活性。采用琼脂稀释法测定，结果显示高良姜素对所有6株金黄色葡萄球菌的最低抑菌浓度（MIC）为25至50微克/毫升，但对其他菌种的活性可忽略不计。芹菜素仅对金黄色葡萄球菌表现出微弱活性，而黄芩苷未检测到活性。在抑制曲线研究中，高良姜素在处理的前两小时内使生长中的金黄色葡萄球菌NCTC 6571菌液的活力降低了100,000倍。同时也观察到金黄色葡萄球菌NCTC 11561和NCIMB 9968菌液的活力下降。
