Mason G A, Noonan L R, Garbutt J C, Caldwell J D, Shimoda K, Walker C H, Li L, Prange A J
Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill 27599.
Alcohol Clin Exp Res. 1992 Dec;16(6):1130-7. doi: 10.1111/j.1530-0277.1992.tb00709.x.
The effects of a high dextrose liquid diet containing ethanol and two different control liquid diets on serum and brain thyroid axis hormones and liver and brain deiodinase activities were studied in groups of adult male Fischer-344 (F-344) rats. Rats received either lab chow, ad libitum; a nutritionally complete 10% (w/v) ethanol liquid diet, ad libitum; a volume of either a high carbohydrate (HC) or a high fat (HF) isocaloric control liquid diet equal to the volume of diet consumed by rats given the ethanol diet; or the HC control diet, ad libitum. Consumption of liquid diets was measured daily and body weights recorded every other day throughout the study. Hormones were measured after 2, 4, or 8 weeks and deiodinase activities after 4 or 8 weeks. Also, groups of rats were given the 10% ethanol diet, ad libitum, or pair-fed the HC control diet intermittently for 8 weeks, and thyroid hormones and thyroid-stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH) were determined. Within 2 weeks rats became accustomed to all diets and thereafter weight gain was comparable in all groups. Small differences between serum thyroid hormones of rats fed the ethanol diet and pair-fed HC or HF controls may have been caused by lower T4 secretion in ethanol-fed rats. Marked differences in free and total T4 and T3 between F-344 rats fed liquid diets for 4 or 8 weeks and rats fed lab chow probably resulted from higher liver 5'-deiodinase activity in rats fed liquid diets.(ABSTRACT TRUNCATED AT 250 WORDS)
在成年雄性Fischer - 344（F - 344）大鼠组中，研究了含乙醇的高葡萄糖液体饮食以及两种不同的对照液体饮食对血清和脑甲状腺轴激素、肝脏和脑脱碘酶活性的影响。大鼠分别自由摄取实验室饲料；自由摄取营养完整的10%（w/v）乙醇液体饮食；摄取与给予乙醇饮食的大鼠所消耗饮食体积相等的高碳水化合物（HC）或高脂肪（HF）等热量对照液体饮食；或自由摄取HC对照饮食。在整个研究过程中，每天测量液体饮食的摄入量，每隔一天记录体重。在2周、4周或8周后测量激素水平，在4周或8周后测量脱碘酶活性。此外，将大鼠组自由给予10%乙醇饮食或间歇性配对喂食HC对照饮食8周，并测定甲状腺激素和促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）的反应。2周内大鼠适应了所有饮食，此后所有组的体重增加相当。喂食乙醇饮食的大鼠与配对喂食HC或HF对照的大鼠血清甲状腺激素之间的微小差异可能是由于喂食乙醇的大鼠T4分泌较低所致。喂食液体饮食4周或8周的F - 344大鼠与喂食实验室饲料的大鼠之间游离和总T4及T3的显著差异可能是由于喂食液体饮食的大鼠肝脏5'-脱碘酶活性较高所致。（摘要截取自250字）
