Mason G A, Stanley D A, Walker C H, Hashimoto H, Noonan L R, Prange A J
Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill 27599.
Alcohol Clin Exp Res. 1988 Dec;12(6):731-4. doi: 10.1111/j.1530-0277.1988.tb01336.x.
In a chronic feeding study adult male Fischer-344 rats (n = 12) were fed a nutritionally complete liquid diet containing 10% (w/v) ethanol for 40 days while control animals (n = 12) were pair fed a nutritionally complete isocaloric diet in which dextrose was substituted for ethanol. Treated animals were gradually introduced to and withdrawn from the 10% diet. At the end of the study and at sacrifice ethanol-fed rats had gained slightly more weight than pair-fed controls. They also showed a significant decrease in total thyroxine, free thyroxine, L-triiodothyronine, reverse L-triiodothyronine, and basal thyroid-stimulating hormone. These differences did not appear to result from caloric deprivation alone. Possible explanations for some of these thyroidal changes are discussed.
在一项慢性喂养研究中，成年雄性Fischer-344大鼠（n = 12）被喂食含10%（w/v）乙醇的营养完全的液体饮食40天，而对照动物（n = 12）被配对喂食用葡萄糖替代乙醇的营养完全的等热量饮食。对接受处理的动物逐渐引入和撤出10%的饮食。在研究结束时及处死时，喂食乙醇的大鼠体重增加略多于配对喂食的对照。它们还表现出总甲状腺素、游离甲状腺素、L-三碘甲状腺原氨酸、反式L-三碘甲状腺原氨酸和基础促甲状腺激素显著降低。这些差异似乎并非仅由热量剥夺导致。文中讨论了其中一些甲状腺变化的可能解释。
