Schanker H M, Rachelefsky G, Siegel S, Katz R, Spector S, Rohr A, Rodriquiz C, Woloshin K, Papanek P J
UCLA Medical Center.
Ann Allergy. 1992 Dec;69(6):526-8.
Between December 1989 and June 1990, 1,874 reports of alleged malathion application related illness from repeated spraying of a mixture of malathion corn syrup bait to eradicate a Mediterranean fruit fly infestation in Southern California were received by the Toxics Epidemiology Program of Los Angeles County. Among these complaints were 47 reports of urticaria, 38 reports of angioedema and 213 reports of a nonspecific skin rash. In order to determine whether these alleged skin reactions were the result of an immediate or delayed type of hypersensitivity reaction to malathion or to the corn syrup bait we studied ten subjects referred for testing by the local health department. All ten subjects had no reaction on patch testing. One child exhibited a positive reaction to the bait and one child had irritant reactions to malathion and to the bait. This study documented one case of a possible immediate IgE reaction to malathion bait. Due to the low participation rates in this study, no specific conclusions concerning the rate of sensitivity in the population can be drawn, although it appears that such reactions are uncommon.
1989年12月至1990年6月期间，洛杉矶县毒物流行病学项目收到了1874份关于在南加州反复喷洒马拉硫磷玉米糖浆诱饵以根除地中海实蝇侵扰而引发的所谓与马拉硫磷应用相关疾病的报告。在这些投诉中，有47份荨麻疹报告、38份血管性水肿报告和213份非特异性皮疹报告。为了确定这些所谓的皮肤反应是对马拉硫磷还是对玉米糖浆诱饵的速发型或迟发型超敏反应的结果，我们研究了当地卫生部门转介来进行检测的10名受试者。所有10名受试者在斑贴试验中均无反应。一名儿童对诱饵呈阳性反应，一名儿童对马拉硫磷和诱饵有刺激性反应。这项研究记录了1例可能对马拉硫磷诱饵产生的速发型IgE反应。由于本研究的参与率较低，尽管此类反应似乎不常见，但无法得出关于人群中敏感性发生率的具体结论。
