流感嗜血杆菌肺炎中左氧氟沙星治疗失败
Levofloxacin treatment failure in Haemophilus influenzae pneumonia.
作者信息
Bastida Teresa, Pérez-Vázquez María, Campos José, Cortés-Lletget María Cristina, Román Federico, Tubau Fe, de la Campa Adela G, Alonso-Tarrés Carles
机构信息
Hospital de l'Esperit Sant, Santa Coloma de Gramenet, Barcelona, Spain.
出版信息
Emerg Infect Dis. 2003 Nov;9(11):1475-8. doi: 10.3201/eid0911.030176.
PMID:14718097
Abstract
We describe the first case of failure of oral levofloxacin treatment of community-acquired pneumonia caused by Haemophilus influenzae. The strain showed cross-resistance to fluoroquinolones and carried four mutations in quinolone resistance-determining regions of DNA gyrase and topoisomerase IV genes.
摘要
我们描述了首例口服左氧氟沙星治疗流感嗜血杆菌引起的社区获得性肺炎失败的病例。该菌株对氟喹诺酮类药物表现出交叉耐药性，并且在DNA旋转酶和拓扑异构酶IV基因的喹诺酮耐药决定区域携带四处突变。
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