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普通人群中晨起头痛的患病率及危险因素。

Prevalence and risk factors of morning headaches in the general population.

作者信息

Ohayon Maurice M

机构信息

Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, Stanford, Calif. 94303, USA.

出版信息

Arch Intern Med. 2004 Jan 12;164(1):97-102. doi: 10.1001/archinte.164.1.97.

Abstract

OBJECTIVE

To determine the prevalence of chronic morning headaches (CMH) in the general population and their relationship to sociodemographic characteristics, psychoactive substance use, and organic, sleep, and mental disorders.

METHODS

A telephone questionnaire was submitted to 18 980 individuals 15 years or older and representative of the general populations of the United Kingdom, Germany, Italy, Portugal, and Spain. It included a series of questions about morning headaches, organic disorders, use of psychoactive substances, and sleep and mental disorders in accordance with the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV).

RESULTS

Overall, the prevalence of CMH was 7.6% (n = 1442); CMH were reported to occur "daily" by 1.3% of the sample, "often" by 4.4%, and "sometimes" by 1.9%. Rates were higher in women than in men (8.4% vs 6.7%) and in subjects aged between 45 and 64 years (about 9%). The median duration for CMH was 42 months. Various conditions and disorders were found positively associated with CMH. The most significant associated factors were comorbid anxiety and depressive disorders (28.5% vs 5.5%), major depressive disorder alone (21.3% vs 5.5%), dyssomnia not otherwise specified (17.1% vs 6.9%), insomnia disorder (14.4% vs 6.9%), and circadian rhythm disorder (20.0% vs 7.5%). Sleep-related breathing disorder (15.2% vs 7.5%), hypertension (11.0% vs 7.2%), musculoskeletal diseases (14.1% vs 7.1%), use of anxiolytic medication (20.1% vs 7.3%), and heavy alcohol consumption (12.6% vs 7.7%) were also significantly associated with CMH.

CONCLUSIONS

Morning headache affects 1 individual in 13 in the general population. Chronic morning headaches are a good indicator of major depressive disorders and insomnia disorders. Contrary to what was previously suggested, however, they are not specific to sleep-related breathing disorder.

摘要

目的

确定普通人群中慢性晨起头痛(CMH)的患病率及其与社会人口学特征、精神活性物质使用、器质性疾病、睡眠障碍和精神障碍的关系。

方法

对18980名15岁及以上、代表英国、德国、意大利、葡萄牙和西班牙普通人群的个体进行电话问卷调查。问卷包含一系列关于晨起头痛、器质性疾病、精神活性物质使用以及符合《精神疾病诊断与统计手册》第四版(DSM-IV)的睡眠障碍和精神障碍的问题。

结果

总体而言,CMH的患病率为7.6%(n = 1442);样本中有1.3%的人报告晨起头痛“每天”发作,4.4%的人“经常”发作,1.9%的人“有时”发作。女性患病率高于男性(8.4%对6.7%),45至64岁人群的患病率更高(约9%)。CMH的中位持续时间为42个月。发现多种情况和疾病与CMH呈正相关。最显著的相关因素是共病焦虑和抑郁障碍(28.5%对5.5%)、单独的重度抑郁障碍(21.3%对5.5%)、未另行规定的睡眠障碍(17.1%对6.9%)、失眠症(14.4%对6.9%)以及昼夜节律障碍(20.0%对7.5%)。睡眠相关呼吸障碍(15.2%对7.5%)、高血压(11.0%对7.2%)、肌肉骨骼疾病(14.1%对7.1%)、使用抗焦虑药物(20.1%对7.3%)以及大量饮酒(12.6%对7.7%)也与CMH显著相关。

结论

晨起头痛在普通人群中每13人中就有1人受影响。慢性晨起头痛是重度抑郁障碍和失眠症的良好指标。然而,与之前的观点相反,它们并非睡眠相关呼吸障碍所特有。

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