Kuzuya Masafumi, Iguchi Akihisa
Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
J Atheroscler Thromb. 2003;10(5):275-82. doi: 10.5551/jat.10.275.
Vascular remodeling, defined as lasting structural changes in the vessel wall in response to hemodynamic stimuli, plays a role in many (patho)physiological processes requiring cell migration and degradation of extracellular matrix(ECM). Matrix metalloproteinase(MMP) system can degrade most ECM components. Several lines of evidence support a role for MMP system components in the development and progression of atherosclerosis and restenosis after angioplasty. This review article focuses on the role of MMPs in vascular remodeling relevant to atherosclerosis and restenosis after angioplasty.
血管重塑被定义为血管壁对血流动力学刺激做出的持久结构变化，在许多需要细胞迁移和细胞外基质（ECM）降解的（病理）生理过程中发挥作用。基质金属蛋白酶（MMP）系统能够降解大多数ECM成分。多条证据支持MMP系统成分在动脉粥样硬化发展以及血管成形术后再狭窄过程中发挥作用。这篇综述文章聚焦于MMPs在与动脉粥样硬化及血管成形术后再狭窄相关的血管重塑中的作用。
