Zedan M M, el-Shennawy F A, Abou-Bakr H M, al-Basousy A M
Department of Paediatrics, Faculty of Medicine, Mansoura University, Egypt.
Arch Dis Child. 1992 Nov;67(11):1373-5. doi: 10.1136/adc.67.11.1373.
Interleukin-2 (IL-2) and T cell subpopulations were evaluated in children with rheumatic heart disease (RHD). Three groups were included: 13 patients with active RHD, 12 with non-active RHD, and 14 control children. Serum IL-2 and T cell subpopulations were measured by radioimmunoassay and monoclonal antibodies respectively. Patients with active RHD showed a significant increase in IL-2 concentrations and helper:suppressor (H:S) ratio compared with controls with a mean (SEM) IL-2 of 3.48 (0.62) v 1.26 (0.16) U/ml and H:S ratio 2.31 (0.14) v 1.66 (0.04). There was a significant decrease in T suppressor (CD8+) and pan T (CD3+) cells compared with controls with a mean (SEM) for CD8+ of 23.75 (1.19) v 32.23 (0.56)% and CD3+ of 79.55 (0.94) v 85.00 (0.11)%. Patients with non-active RHD showed a significant decrease only in the CD3+ cells (78.20 (0.20)%) when compared with controls. A deficiency of CD3+ cells is a constant finding in patients with RHD, whether the disease is active or not. There was a significant increase in IL-2 concentration with a significant decrease in CD8+ cells in patients with active RHD in comparison with the non-active group (mean (SEM) IL-2 of 3.48 (0.62) v 1.85 (0.24) U/ml and CD8+ of 23.75 (1.19) v 28.83 (1.91)%). Thus an increase in IL-2 and a decrease in CD8+ cells may be related to rheumatic activity. T helper (CD4+) cells did not differ significantly between groups.
对风湿性心脏病（RHD）患儿的白细胞介素-2（IL-2）和T细胞亚群进行了评估。研究纳入了三组：13例活动性RHD患者、12例非活动性RHD患者和14名对照儿童。分别采用放射免疫测定法和单克隆抗体检测血清IL-2和T细胞亚群。与对照组相比，活动性RHD患者的IL-2浓度和辅助性T细胞与抑制性T细胞比值（H:S）显著升高，IL-2的平均（标准误）浓度为3.48（0.62）U/ml，而对照组为1.26（0.16）U/ml；H:S比值为2.31（0.14），而对照组为1.66（0.04）。与对照组相比，T抑制性细胞（CD8+）和全T细胞（CD3+）显著减少，CD8+的平均（标准误）比例为23.75（1.19）%，而对照组为32.23（0.56）%；CD3+的平均（标准误）比例为79.55（0.94）%，而对照组为85.00（0.11）%。与对照组相比，非活动性RHD患者仅CD3+细胞显著减少（78.20（0.20）%）。无论疾病是否活动，RHD患者中CD3+细胞缺乏是一个持续存在的现象。与非活动性组相比，活动性RHD患者的IL-2浓度显著升高，CD8+细胞显著减少（IL-2的平均（标准误）浓度为3.48（0.62）U/ml，而非活动性组为1.85（0.24）U/ml；CD8+为23.75（1.19）%，而非活动性组为28.83（1.91）%）。因此，IL-2升高和CD8+细胞减少可能与风湿活动有关。各组间T辅助性细胞（CD4+）无显著差异。
