卵巢切除术、干扰素α-2b及他莫昔芬治疗淋巴管平滑肌瘤病——1例报告
Treatment of lymphangioleiomyomatosis by ovariectomy, interferon alpha 2b and tamoxifen--a case report.
作者信息
Klein M, Krieger O, Ruckser R, Rosen A, Waldner R, Preis P, Beck A
机构信息
Department of Gynecology and Obstetrics, Hanusch-Krankenhaus, Vienna, Austria.
出版信息
Arch Gynecol Obstet. 1992;252(2):99-102. doi: 10.1007/BF02389635.
The gender-specific prevalence of lymphangioleiomyomatosis (LAM) in premenopausal women suggests a hormonal etiology. Despite the antiestrogenic treatment (ovariectomy, tamoxifen) this disease is often refractory to therapy and almost inevitably leads to the patient's death. We describe a case where the antiproliferative effect of systemically applied interferon alpha 2b was successfully employed in addition to ovariectomy and the patient reached complete remission.
淋巴管平滑肌瘤病（LAM）在绝经前女性中的性别特异性患病率提示其病因与激素有关。尽管采用了抗雌激素治疗（卵巢切除术、他莫昔芬），但这种疾病通常对治疗难治，几乎不可避免地导致患者死亡。我们描述了一例除卵巢切除外，全身应用干扰素α2b的抗增殖作用成功应用，患者达到完全缓解的病例。
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