[长期低剂量2,4-二氯苯酚暴露对鲫鱼肝脏抗氧化防御系统的影响]
[Effects of long-term exposure of low-level 2,4-dichlorophenol on the antioxidant defense system in liver of Carassius auratus].
作者信息
Zhang Jingfei, Wang Xiaorong
机构信息
State Key Laboratory of Pollution Control and Resources Reuse, School of Environment, Nanjing University, Nanjing 210093, China.
出版信息
Huan Jing Ke Xue. 2003 Sep;24(5):136-40.
Under the indoors simulant conditions, the effects of long-term exposure of low-level 2,4-Dichlorophenol on the antioxidant system of larval fishes were studied. The results showed that the activities of catalase (CAT), sedium-dependent glutathione peroxidase (Se-GPx) and the content of oxidized glutathione (GSSG) were induced significantly. The activity of superoxide dismutase (SOD) was induced remarkably when 2,4-Dichlorophenol level was at only 0.005 mg.L-1; the content of reduce glutathione (GSH) was almost suppressed continuously; the activity of glutathione reductase was inhibited firstly and then restored gradually; the activity of glutathione S-transferase (GST) had slight variances among groups. GR, GSH, especially SOD, can act as an early monitoring index of 2,4-Dichlorophenol pollution in aquatic ecosystem.
在室内模拟条件下，研究了低浓度2,4-二氯苯酚长期暴露对幼鱼抗氧化系统的影响。结果表明，过氧化氢酶（CAT）、硒依赖性谷胱甘肽过氧化物酶（Se-GPx）的活性以及氧化型谷胱甘肽（GSSG）的含量均显著升高。当2,4-二氯苯酚浓度仅为0.005 mg·L-1时，超氧化物歧化酶（SOD）的活性显著升高；还原型谷胱甘肽（GSH）的含量几乎持续受到抑制；谷胱甘肽还原酶的活性先被抑制，然后逐渐恢复；谷胱甘肽S-转移酶（GST）的活性在各组间有轻微变化。GR、GSH，尤其是SOD，可作为水生生态系统中2,4-二氯苯酚污染的早期监测指标。
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