Silvia Wilma Delphine, Biswas Sharmistha, Uthappa Sheila, Shetty P
Department of Biochemistry and Biophysics, St. John's National Academy of Health Sciences, Bangalore, India.
J Assoc Physicians India. 2003 Oct;51:947-50.
Studies conducted have yielded contradicting results on the role of ferritin as a risk factor for acute myocardial infarction (AMI). The relation of ferritin status to risk of AMI in Indian men, along with other established major risk factors like serum total cholesterol, HDL cholesterol, LDL cholesterol, VLDL cholesterol and triglycerides has not been documented previously. The hypothesis that increased serum ferritin was related to increased chances of AMI along with the risk factors was tested.
Case control study involving 145 men (100 cases and 45 healthy control subjects) in the age group of 30-70 years. Serum ferritin levels were estimated by using ELISA, and other risk factors by enzymatic methods.
Increased serum ferritin levels significantly (p < 0.001) correlated with an increase of other risk factors in Indian male patients with AMI.
Significant direct correlation between serum ferritin levels and risk of AMI was observed.
关于铁蛋白作为急性心肌梗死（AMI）风险因素的作用，已开展的研究得出了相互矛盾的结果。此前尚未有文献记录印度男性中铁蛋白状态与AMI风险的关系，以及血清总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇和甘油三酯等其他已确定的主要风险因素。本研究检验了血清铁蛋白升高与AMI发生几率增加以及风险因素相关的假设。
病例对照研究纳入了145名年龄在30 - 70岁之间的男性（100例病例和45名健康对照者）。采用ELISA法测定血清铁蛋白水平，采用酶法测定其他风险因素。
在印度男性AMI患者中，血清铁蛋白水平升高与其他风险因素增加显著相关（p < 0.001）。
观察到血清铁蛋白水平与AMI风险之间存在显著的直接相关性。
