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密度对10兆伏光子束半值层的影响。

The effect of density on the 10MV photon beam penumbra.

作者信息

Hoban P W, Keal P J, Round W H

机构信息

Department of Medical Physics, Royal Adelaide Hospital, Australia.

出版信息

Australas Phys Eng Sci Med. 1992 Sep;15(3):113-23.

PMID:1471961
Abstract

An investigation into the density dependence of the penumbra of the Varian Clinac 18/10 10MV photon beam has been carried out. A water/lung phantom was constructed of polystyrene (r = 1.04 g cm-3) and cork (r = 0.23 g cm-3), in which interfaces exist both parallel and perpendicular to the beam axis. The irradiation of the phantom was also simulated using the EGS4 Monte Carlo system with a cartesian voxel geometry. Experimental (TLD) and Monte Carlo dose profiles are in close agreement, and show a large degree of penumbral broadening in the lung region. This broadening is due primarily to lateral electronic disequilibrium occurring at a larger distance from the geometric beam edge in lung than in water. This disequilibrium can also cause the dose in lung to drop below the dose in water at the same depth and off axis distance, even though the radiological depth is less in lung. Monte Carlo simulations were also performed where the dose is separated into primary and scattered components, for homogeneous media of densities 0.25, 0.50, 0.75 and 1.00 g cm-3. The penumbral width of the primary dose profile was found to be almost constant with depth for a point source of photons (after the initial build-up region), where the lateral distances from the 95-50% and 50-5% dose levels on the dose profile (normalised to the dose at the central axis) are equal in all cases. Also, primary penumbra width was found to be almost inversely proportional to density. The primary penumbra for a unit density material can be fitted accurately by an exponential forming function with empirical determined coefficients. The penumbral shape for the lower densities can then be closely fitted by scaling the coefficients in proportion to density. This scaling method has application in treatment planning, where the predicted primary penumbra shape should take account of inhomogeneities, and is particularly important in matching adjacent fields. When the scattered dose component is added to give the total dose, penumbral width increases because the scattered dose penumbra is wider than that of the primary dose. Also, the inverse proportionality of the penumbra width with density does not hold for the scattered dose. The relative contribution of the scattered dose increases with density. Therefore, the inverse proportionality of penumbra width with density does not hold for the total dose.

摘要

已对瓦里安Clinac 18/10 10MV光子束半影的密度依赖性进行了研究。使用聚苯乙烯(r = 1.04 g/cm³)和软木(r = 0.23 g/cm³)构建了水/肺模体,其中存在与束轴平行和垂直的界面。还使用具有笛卡尔体素几何形状的EGS4蒙特卡罗系统模拟了模体的照射。实验(TLD)和蒙特卡罗剂量分布结果吻合良好,并显示出肺区域存在很大程度的半影展宽。这种展宽主要是由于与水中相比,肺中在距几何束边缘更大距离处发生了横向电子不平衡。即使肺中的放射学深度较小,这种不平衡也会导致在相同深度和离轴距离处肺中的剂量低于水中的剂量。还对密度为0.25、0.50、0.75和1.00 g/cm³的均匀介质进行了蒙特卡罗模拟,将剂量分为原发射线剂量分量和散射剂量分量。对于光子点源,发现原发射线剂量分布的半影宽度在初始建成区之后随深度几乎保持恒定,在所有情况下,剂量分布上95 - 50%和50 - 5%剂量水平到中心轴剂量的归一化横向距离相等。此外,发现原发射线半影宽度几乎与密度成反比。单位密度材料的原发射线半影可以用具有经验确定系数的指数形成函数精确拟合。然后,通过按密度比例缩放系数,可以紧密拟合较低密度下的半影形状。这种缩放方法在治疗计划中有应用,其中预测的原发射线半影形状应考虑不均匀性,并且在匹配相邻射野时尤为重要。当加入散射剂量分量以得到总剂量时,半影宽度会增加,因为散射剂量半影比原发射线剂量半影更宽。而且,半影宽度与密度的反比关系对于散射剂量不成立。散射剂量的相对贡献随密度增加。因此,半影宽度与密度的反比关系对于总剂量不成立。

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