Yawn Barbara P, Wollan Peter C, Schroeder Clayton, Gazzuola Lilianna, Mehta Minesh
Olmsted Medical Center, Rochester, USA.
Minn Med. 2003 Dec;86(12):32-7.
Increased duration of cancer survival may allow a longer window for detection of metastases, including brain metastases. Using the entire population of Olmsted County, Minnesota, we looked at trends in the rate of brain metastases in people diagnosed with primary lung or breast cancers between January 1, 1988, and December 31, 2001. Yearly rates of brain metastases detection following the primary tumors were calculated from a combination of medical record and SEER database information. Trends in rates and gender differences were assessed. There was no discernible increase in the rates of brain metastases secondary to lung or breast cancer during the period of observation. However, women were twice as likely as men to have brain metastases detected following a primary lung cancer. This difference was constant over the time period. This twofold difference in brain metastases detected in women versus men with lung cancer deserves further evaluation and confirmation.
癌症生存期的延长可能会为转移灶（包括脑转移灶）的检测提供更长的窗口期。我们利用明尼苏达州奥尔姆斯特德县的全体居民数据，研究了1988年1月1日至2001年12月31日期间被诊断为原发性肺癌或乳腺癌的患者发生脑转移的比率趋势。根据病历和监测、流行病学与最终结果（SEER）数据库信息的综合数据，计算出原发性肿瘤后每年的脑转移检测率。评估了比率趋势和性别差异。在观察期内，继发于肺癌或乳腺癌的脑转移率没有明显增加。然而，原发性肺癌后检测到脑转移的女性可能性是男性的两倍。这一差异在整个时间段内保持不变。女性与男性肺癌患者脑转移检测的这两倍差异值得进一步评估和确认。
