Gomez-Merino Danielle, Chennaoui Mounir, Burnat Pascal, Drogou Catherine, Guezennec Charles Yannick
Department of Physiology, Institut de Médecine Aérospatiale du Service de Santé des Armies, BP 73, 91223 Brétigny-sur-Orge, Cedex France.
Mil Med. 2003 Dec;168(12):1034-8.
This study was designed to determine whether the immune and hormonal systems were affected by a 5-day military course following 3 weeks of combat training in a population of 26 male soldiers (mean age, 21 +/- 2 years). The combination of continuous heavy physical activity and sleep deprivation led to energy deficiency. At the beginning of the training program and immediately after the combat course, saliva samples were assayed for secretory immunoglobulin A and plasma samples were assayed for interleukin-6, dehydroepiandrosterone sulfate, prolactin, catecholamines, glucocorticoids, and testosterone. Secretory immunoglobulin A was lower and circulating interleukin-6 was increased by the end of the course, which was attributed to sympathoadrenergic stimulation. Dehydroepiandrosterone sulfate, prolactin, and testosterone levels fell significantly. These results suggest that prolonged and repeated exercise such as that encountered in a military training program induces immune impairment via a decrease in mucosal immunity and a release of interleukin-6 into the circulation. The impaired secretion of dehydroepiandrosterone sulfate and prolactin, two immunomodulatory hormones, was thought to be a response to the chronic stressors. Lowered testosterone reflects a general decrease in steroid synthesis as a consequence of the physical and psychological strain.
本研究旨在确定在26名男性士兵（平均年龄21±2岁）中，经过3周战斗训练后进行为期5天的军事课程是否会影响免疫和激素系统。持续的高强度体力活动和睡眠剥夺相结合导致能量缺乏。在训练计划开始时以及战斗课程结束后立即采集唾液样本检测分泌型免疫球蛋白A，采集血浆样本检测白细胞介素-6、硫酸脱氢表雄酮、催乳素、儿茶酚胺、糖皮质激素和睾酮。课程结束时，分泌型免疫球蛋白A降低，循环白细胞介素-6增加，这归因于交感肾上腺素能刺激。硫酸脱氢表雄酮、催乳素和睾酮水平显著下降。这些结果表明，军事训练计划中遇到的长时间反复运动通过黏膜免疫下降和白细胞介素-6释放到循环中诱导免疫损伤。硫酸脱氢表雄酮和催乳素这两种免疫调节激素的分泌受损被认为是对慢性应激源的反应。睾酮降低反映了由于身体和心理压力导致类固醇合成普遍减少。
