Cumming D C, Brunsting L A, Strich G, Ries A L, Rebar R W
Med Sci Sports Exerc. 1986 Aug;18(4):369-73.
The increase in serum testosterone levels generally observed with intense, short-term exercise remains unexplained since most investigators have not reported any increase in the levels of luteinizing hormone, the pituitary glycoprotein most responsible for testicular steroidogenesis. Hemoconcentration and decreased metabolic clearance have been suggested as mechanisms to explain the exercise-associated testosterone increase. Such non-specific mechanisms should apply to other steroid hormones as well as to testosterone. To investigate whether the exercise-induced changes in other steroid hormones were similar to that of testosterone, we measured serum levels of testosterone, androstenedione, dehydroepiandrosterone, and cortisol as well as gonadotropins, luteinizing hormone and follicle-stimulating hormone, and prolactin at 5-15 min intervals throughout progressive maximal intensity exercise on a cycle ergometer. Significant increases were observed with all hormones with exercise. The increase in serum testosterone began prior to exercise, peaked at 20 min after the beginning of exercise, and fell to baseline within 10 min. The serum luteinizing hormone increase was synchronous with that of testosterone, suggesting that gonadotropin stimulation was not responsible for the testosterone increment. The increments in serum cortisol, androstenedione, dehydroepiandrosterone, and prolactin levels were simultaneous but began 25-30 min after that of testosterone in all subjects. These findings, therefore, suggest that, contrary to previous evidence, the exercise-associated increase in serum testosterone results predominantly from a specific mechanism, presumably involving increased testicular production without gonadotropin stimulation.
一般在剧烈的短期运动中观察到的血清睾酮水平升高现象仍无法解释，因为大多数研究人员并未报告促黄体生成素（对睾丸类固醇生成最具责任的垂体糖蛋白）水平有任何升高。血液浓缩和代谢清除率降低已被提出作为解释运动相关睾酮升高的机制。这种非特异性机制应该也适用于其他类固醇激素以及睾酮。为了研究运动引起的其他类固醇激素变化是否与睾酮相似，我们在使用自行车测力计进行递增最大强度运动的整个过程中，每隔5 - 15分钟测量血清睾酮、雄烯二酮、脱氢表雄酮、皮质醇以及促性腺激素、促黄体生成素、促卵泡激素和催乳素的水平。运动时所有激素水平均显著升高。血清睾酮水平在运动前就开始升高，在运动开始后20分钟达到峰值，并在10分钟内降至基线。血清促黄体生成素的升高与睾酮同步，这表明促性腺激素刺激并非睾酮升高的原因。在所有受试者中，血清皮质醇、雄烯二酮、脱氢表雄酮和催乳素水平的升高是同时发生的，但比睾酮升高晚25 - 30分钟。因此，这些发现表明，与先前的证据相反，运动相关的血清睾酮升高主要源于一种特定机制，可能涉及在无促性腺激素刺激的情况下睾丸生成增加。
