多组分反应在水中会加速进行。
Multicomponent reactions are accelerated in water.
作者信息
Pirrung Michael C, Sarma Koushik Das
机构信息
Department of Chemistry, Levine Science Research Center, Duke University, Durham, North Carolina, 27708, USA.
出版信息
J Am Chem Soc. 2004 Jan 21;126(2):444-5. doi: 10.1021/ja038583a.
Two multicomponent reactions, the Ugi and Passerini reactions, are accelerated by the use of aqueous solutions. The rate enhancements compared to those by organic solvents can approach 300-fold. Reactions performed in water offer another advantage that products are often insoluble, permitting direct isolation by precipitation. The methods were applied to the preparation of three small combinatorial libraries.
乌吉反应（Ugi反应）和帕瑟里尼反应（Passerini反应）这两种多组分反应，通过使用水溶液可加快反应速度。与使用有机溶剂相比，反应速率提高可达300倍。在水中进行的反应还有另一个优点，即产物通常不溶，可通过沉淀直接分离。这些方法已应用于三个小型组合文库的制备。
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