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[Expression of survivin and caspase-3 in non-Hodgkin's lymphoma and their clinical significance].

作者信息

Li Hong-Ling, Sun Bing-Zhong, Feng Qi, Shang Zhen-Chuan

机构信息

Department of Hematology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710033, P.R.China.

出版信息

Ai Zheng. 2004 Jan;23(1):40-3.

PMID:14720372
Abstract

BACKGROUND & OBJECTIVE: Survivin, a member of the inhibitor of apoptosis protein (IAP) family, can directly inhibit caspase-3 and caspase-7 activity and plays an important role in oncogenesis. This study was designed to investigate the expression of survivin and caspases-3 in non-Hodgkin's lymphoma (NHL) with different aggressiveness and their clinical significance.

METHODS

The expression of survivin and caspase-3 in 54 cases of NHL were determined with immunohistochemistry of EnVision.

RESULTS

The expression rates of survivin and caspase-3 were 51.9% (28/54) and 83.3% (45/54), respectively. The expression of survivin in NHL patients with low grade malignancy (19%, 4/21) was lower than that of NHL patients with intermediate-high grade malignancy; the difference was statistically significant. The expression of caspase-3 showed the same tendency. Co-expression rate of survivin and caspase-3 was 46.3% (25/54).

CONCLUSION

The expression of survivin is upregulated in NHL.

摘要

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