Fung K S C, Yeung W L, Wong T W, So K W, Cheng A F B
Department of Microbiology, Prince of Wales Hospital, Hong Kong, SAR, People's Republic of China.
J Infect. 2004 Feb;48(2):145-8. doi: 10.1016/s0163-4453(03)00137-3.
Seven cases of pertussis in patients aged between 1 and 6 months detected over 3 months were reported. Paroxysmal cough (six cases), post-tussive vomiting (three cases) and poor feeding (three cases) were the most common presenting symptoms. Bordetella pertussis was isolated from six patients. The total leucocyte counts were mildly increased (10.8-15.6x10(9)/L). The lymphocyte counts were markly raised (59-73%) and appear to be useful indicators of pertussis. It appears that herd immunity does not offer adequate protection to the vulnerable group even in well-vaccinated populations. High vaccination coverage should be maintained, and vaccination should be given as early an age as possible. Aggressive efforts to identify cases and contacts are essential. Health care workers should have a high index of suspicion for pertussis, in particular for those with paroxysmal cough and high lymphocyte counts so as to give timely diagnosis and treatment.
报告了在3个月内检测到的7例年龄在1至6个月之间的百日咳病例。阵发性咳嗽（6例）、咳嗽后呕吐（3例）和喂养困难（3例）是最常见的症状。6例患者分离出百日咳博德特菌。白细胞总数轻度升高（10.8 - 15.6×10⁹/L）。淋巴细胞计数显著升高（59 - 73%），似乎是百日咳的有用指标。即使在疫苗接种率高的人群中，群体免疫似乎也不能为弱势群体提供足够的保护。应保持高疫苗接种覆盖率，并尽早接种疫苗。积极努力识别病例和接触者至关重要。医护人员应对百日咳保持高度怀疑指数，特别是对阵发性咳嗽和淋巴细胞计数高的患者，以便及时诊断和治疗。
