Vanderbilt University School of Medicine, Department of Pediatrics, Vanderbilt Vaccine Research Program, Nashville, TN, USA.
Expert Rev Vaccines. 2012 Nov;11(11):1331-46. doi: 10.1586/erv.12.118.
Whooping cough, due to Bordetella pertussis and Bordetella parapertussis, is an important cause of childhood morbidity and mortality. Despite widespread pertussis immunization in childhood, there are an estimated 50 million cases and 300,000 deaths due to pertussis globally each year. Infants who are too young to be vaccinated, children who are partially vaccinated and fully-vaccinated persons with waning immunity are especially vulnerable to disease. Since pertussis is one of the vaccine-preventable diseases on the rise, additional vaccine approaches are needed. These approaches include vaccination of newborns, additional booster doses for older adolescents and adults, and immunization of pregnant women with existing vaccines. Innovative new vaccines are also being studied. Each of these options will be discussed and their potential impact on pertussis control assessed.
百日咳是由百日咳博德特氏菌和副百日咳博德特氏菌引起的，是导致儿童发病和死亡的一个重要原因。尽管儿童中广泛进行了百日咳免疫接种，但每年仍估计有 5000 万例和 30 万例由百日咳导致的死亡。不能接种疫苗的婴儿、部分接种疫苗的儿童以及免疫力逐渐减弱的完全接种疫苗者特别容易患病。由于百日咳是上升的疫苗可预防疾病之一，因此需要采取额外的疫苗接种措施。这些措施包括对新生儿进行接种、为年龄较大的青少年和成年人接种额外的加强针，以及为孕妇接种现有的疫苗。创新性的新型疫苗也正在研究中。将讨论每种选择，并评估其对百日咳控制的潜在影响。
