De Berry Brittany B, Lynch James E, Chung Dai H, Zwischenberger Joseph B
Department of Surgery, The University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA.
Pediatr Surg Int. 2005 Aug;21(8):692-4. doi: 10.1007/s00383-005-1458-x. Epub 2005 Oct 13.
Pertussis, or "whooping cough," is a highly communicable disease caused by the coccobacillus Bordetella pertussis. Pertussis remains one of the most common causes of death from infectious diseases worldwide. We describe a 5-week-old infant girl who presented with severe pertussis infection associated with extreme leukocytosis and required prolonged extracorporeal membrane oxygenation (ECMO). Nitric oxide therapy resolved the pulmonary hypertension, and she was successfully weaned from ECMO and discharged home after 3 months. We report successful application of ECMO for severe pertussis-induced respiratory failure despite multiple grave prognostic indicators (<1 year age, leukocytosis, pulmonary hypertension) and discuss the role of extracorporeal life support in treating pertussis.
百日咳，又称“小儿咳嗽”，是由百日咳博德特氏菌引起的一种高度传染性疾病。百日咳仍然是全球范围内传染病致死的最常见原因之一。我们描述了一名5周大的女婴，她因严重的百日咳感染并伴有极度白细胞增多症而就诊，需要长时间的体外膜肺氧合（ECMO）治疗。一氧化氮疗法缓解了肺动脉高压，她成功脱离了ECMO，并在3个月后出院回家。我们报告了尽管存在多个严重的预后指标（年龄<1岁、白细胞增多症、肺动脉高压），ECMO在治疗严重百日咳诱发的呼吸衰竭方面仍取得成功，并讨论了体外生命支持在治疗百日咳中的作用。
