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Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range.在 740 至 1400nm 波长范围内对人体主动脉富含脂质斑块的光谱光声成像。
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用于血管内应用的联合频域光声和超声成像。

Combined frequency domain photoacoustic and ultrasound imaging for intravascular applications.

作者信息

Castelino Robin F, Hynes Michael, Munding Chelsea E, Telenkov Sergey, Foster F Stuart

机构信息

Medical Biophysics, University of Toronto, 5 King's College Road, Toronto, ON M5S 3G8, Canada; Imaging Research, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.

Imaging Research, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.

出版信息

Biomed Opt Express. 2016 Oct 6;7(11):4441-4449. doi: 10.1364/BOE.7.004441. eCollection 2016 Nov 1.

DOI:10.1364/BOE.7.004441
PMID:27895986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5119586/
Abstract

Intravascular photoacoustic (IVPA) imaging has the potential to characterize lipid-rich structures based on the optical absorption contrast of tissues. In this study, we explore frequency domain photoacoustics (FDPA) for intravascular applications. The system employed an intensity-modulated continuous wave (CW) laser diode, delivering 1W over an intensity modulated chirp frequency of 4-12MHz. We demonstrated the feasibility of this approach on an agar vessel phantom with graphite and lipid targets, imaged using a planar acoustic transducer co-aligned with an optical fibre, allowing for the co-registration of IVUS and FDPA images. A frequency domain correlation method was used for signal processing and image reconstruction. The graphite and lipid targets show an increase in FDPA signal as compared to the background of 21dB and 16dB, respectively. Use of compact CW laser diodes may provide a valuable alternative for the development of photoacoustic intravascular devices instead of pulsed laser systems.

摘要

血管内光声（IVPA）成像有潜力基于组织的光吸收对比度来表征富含脂质的结构。在本研究中，我们探索用于血管内应用的频域光声（FDPA）。该系统采用强度调制连续波（CW）激光二极管，在4 - 12MHz的强度调制啁啾频率上输出1W功率。我们在带有石墨和脂质靶点的琼脂血管模型上证明了这种方法的可行性，使用与光纤共对准的平面声换能器进行成像，从而实现血管内超声（IVUS）和FDPA图像的配准。频域相关方法用于信号处理和图像重建。与背景相比，石墨和脂质靶点的FDPA信号分别增加了21dB和16dB。使用紧凑型CW激光二极管可能为光声血管内装置的开发提供一种有价值的替代方案，以取代脉冲激光系统。