Reck B, Dingler E, Lohmann A
Battelle-Institut e.V.a, Frankfurt/Main, Fed. Rep. of Germany.
Arzneimittelforschung. 1992 Oct;42(10):1171-4.
An Enzyme immunoassay for the quantitative determination of vinpocetine (CAS-42971-09-5) in human plasma has been developed. The lower limit of quantification is 0.1 ng/ml plasma. The assay shows no cross reactivity with the major metabolite apovincaminic acid. Because of a strong unspecific binding of vinpocetine to plasma proteins an extraction step was necessary. The inter- and intra-assay reproducibility of the test (coefficient of variation) is in a range of 1.1 and 18.3%.
已开发出一种用于定量测定人血浆中长春西汀（CAS-42971-09-5）的酶免疫分析法。定量下限为0.1 ng/ml血浆。该分析方法与主要代谢产物阿朴长春胺酸无交叉反应。由于长春西汀与血浆蛋白有很强的非特异性结合，因此需要进行萃取步骤。该检测方法的批间和批内重现性（变异系数）在1.1%至18.3%范围内。
