Türk Tufan, Pirildar Timur, Tunç Ercan, Bor Serhat, Doğanavşargil Eker
Department of Rheumatology, Division of Internal Medicine, Ege University, Izmir, Turkey.
Rheumatol Int. 2005 May;25(4):246-9. doi: 10.1007/s00296-003-0426-9. Epub 2004 Jan 14.
The aim of this study was to assess the esophageal motility by manometry in patients with primary Sjögren's syndrome.
Esophageal manometry was carried out in 40 patients with primary Sjögren's syndrome (SS), 15 with rheumatoid arthritis (RA), 15 with RA and secondary SS, and 21 healthy volunteers.
We found that the mean lower esophageal sphincter (LES) pressures measured by station pull-through and rapid pull-through techniques were significantly higher in primary SS patients than with healthy controls and RA patients with or without SS (P<0.05). Our study did not show any major differences when comparing the three patient groups (P>0.05). However, peristaltic contraction velocity was lower and peristaltic contraction duration significantly higher at the middle and lower thirds of the esophagus in primary SS patients than in healthy controls (P<0.05).
The results of our study support the view that various esophageal motility disorders can be found in patients with primary SS which could be related to an increase in LES pressure. We also found no correlation of the esophageal abnormalities with other factors studied, suggesting that the cause of dysphagia is multifactorial in nature.
本研究旨在通过测压法评估原发性干燥综合征患者的食管动力。
对40例原发性干燥综合征（SS）患者、15例类风湿关节炎（RA）患者、15例合并继发性SS的RA患者以及21名健康志愿者进行食管测压。
我们发现，采用定点牵拉法和快速牵拉法测得的原发性SS患者食管下括约肌（LES）平均压力显著高于健康对照组以及合并或未合并SS的RA患者（P<0.05）。比较三组患者时，我们的研究未显示出任何重大差异（P>0.05）。然而，原发性SS患者食管中下段的蠕动收缩速度较低，蠕动收缩持续时间显著长于健康对照组（P<0.05）。
我们的研究结果支持以下观点，即原发性SS患者可出现多种食管动力障碍，这可能与LES压力升高有关。我们还发现食管异常与所研究的其他因素无相关性，这表明吞咽困难的原因本质上是多因素的。
