Talvani Andre, Rocha Manoel O C, Ribeiro Antonio L, Correa-Oliveira Rodrigo, Teixeira Mauro M
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Belo Horizonte, Minas Gerais, Brazil.
J Infect Dis. 2004 Jan 15;189(2):214-20. doi: 10.1086/380803. Epub 2004 Jan 8.
We evaluated the expression of chemokine receptors (CCR1, CCR2, CCR5, and CXCR4) on the surface of peripheral blood mononuclear cells obtained from patients with chronic chagasic cardiomyopathy (CCC) and noninfected individuals. Only CCR5 and CXCR4 expression was different on the surface of the subsets (CD4, CD8, and CD14) evaluated. Patients with mild CCC had elevated leukocyte expression of CCR5, compared with noninfected individuals or those with severe disease. CXCR4 expression was lower on leukocytes from patients with severe CCC. The differential expression of both receptors on leukocytes of patients with CCC was consistent and clearly correlated with the degree of heart function such that the lower the heart function, the lower the expression of either CCR5 or CXCR4. These results highlight the possible participation of the chemokine system in early forms of chagasic cardiomyopathy and the relevance of heart failure-induced remodeling in modifying immune parameters in infected individuals.
我们评估了慢性恰加斯病性心肌病（CCC）患者和未感染个体外周血单个核细胞表面趋化因子受体（CCR1、CCR2、CCR5和CXCR4）的表达情况。在所评估的亚群（CD4、CD8和CD14）表面，只有CCR5和CXCR4的表达存在差异。与未感染个体或重症患者相比，轻度CCC患者白细胞中CCR5的表达升高。重症CCC患者白细胞上的CXCR4表达较低。CCC患者白细胞上这两种受体的差异表达是一致的，且与心功能程度明显相关，即心功能越低，CCR5或CXCR4的表达越低。这些结果突出了趋化因子系统在恰加斯病性心肌病早期形式中的可能参与，以及心力衰竭诱导的重塑在改变感染个体免疫参数方面的相关性。
