Nagaraja H S, Jeganathan P S
Department of Physiology, Kasturba Medical College, Center for Basic Sciences, Bejai, Mangalore 575 004.
Indian J Physiol Pharmacol. 2003 Jul;47(3):325-31.
Male albino rats of Wistar strain were exposed to overcrowding stress in two different groups for a period of seven days. One group of rats was kept under stress for six hours per day (acute stressed group) and the other group rats was kept under stress continuously (chronic stressed group). The effect of these acute and chronic stresses on voluntary alcohol (2% w/v) intake was monitored during the 7 days of stress exposure, and ethanol preference and total ethanol intake in terms of g/kg body weight were also studied. A significant increase in ethanol preference and ethanol intake was observed in one-day and 7 days chronic stressed group. No significant increase in ethanol intake was observed in acute stress. Thus a short lasting stressor may not increase ethanol-drinking behavior, whereas when animals were exposed to more intense stressor continuously for 7 days, an increase in voluntary drinking behavior may be seen.
将Wistar品系的雄性白化大鼠分为两组，使其暴露于拥挤应激环境中，持续7天。一组大鼠每天处于应激状态6小时（急性应激组），另一组大鼠持续处于应激状态（慢性应激组）。在应激暴露的7天期间，监测这些急性和慢性应激对自愿酒精（2% w/v）摄入量的影响，同时还研究了乙醇偏好以及以克/千克体重计的总乙醇摄入量。在慢性应激1天和7天的组中，观察到乙醇偏好和乙醇摄入量显著增加。在急性应激中未观察到乙醇摄入量有显著增加。因此，短暂的应激源可能不会增加饮酒行为，而当动物连续7天暴露于更强的应激源时，可能会出现自愿饮酒行为增加的情况。
