Parker Kathlyn A, Lim Yeon-Hee
Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York, 11794-3400, USA.
Org Lett. 2004 Jan 22;6(2):161-4. doi: 10.1021/ol036048+.
[reaction: see text] A tandem electrocyclic closure, perceived as the key step in a biomimetic approach to SNF 4435C and D, was tested with 1,1,8-trisubstituted tetraene substrates. The ratio of endo:exo products could be controlled by the choice of the RZ substituent at C-1. On the basis of these results, a short stereoselective route to an advanced SNF 4435 intermediate was devised.
[反应：见正文] 串联电环化闭环反应被视为仿生合成SNF 4435C和D方法中的关键步骤，该反应在1,1,8-三取代四烯底物上进行了测试。内型：外型产物的比例可通过选择C-1位的RZ取代基来控制。基于这些结果，设计了一条通往高级SNF 4435中间体的短立体选择性路线。
