一种新型C2对称硫脲的合成及其在有氧条件下与芳基重氮盐的钯催化交叉偶联反应中的应用。
Synthesis of a novel C2-symmetric thiourea and its application in the Pd-catalyzed cross-coupling reactions with arenediazonium salts under aerobic conditions.
作者信息
Dai Mingji, Liang Bo, Wang Cuihua, Chen Jiahua, Yang Zhen
机构信息
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing, 100871 China.
出版信息
Org Lett. 2004 Jan 22;6(2):221-4. doi: 10.1021/ol036182u.
[reaction: see text] A novel thiourea-based C2-symmetric ligand was synthesized, and its application in the palladium-catalyzed Heck and Suzuki coupling reactions of arenediazonium salts was evaluated. The reactions, which were performed at room temperature, without added base, and under aerobic conditions, produced product in 4 h with good yield. The corresponding arenediazonium salts were easily generated in one step from anilines.
[反应：见正文] 合成了一种新型的基于硫脲的C2对称配体，并评估了其在钯催化的芳基重氮盐的Heck和Suzuki偶联反应中的应用。该反应在室温下、无碱添加且有氧条件下进行，4小时内即可生成产物，产率良好。相应的芳基重氮盐可由苯胺一步轻松制得。
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